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Humira (Abbott Laboratories): Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Humira (Abbott Laboratories) - General Information

Anti-TNF antibody, expressed in mammalian cell culture, 1330 residues, MW=148 kD. Humira was created using phage display technology resulting in an antibody with human derived heavy and light chain variable regions and human IgGl:K constant regions. It is produced by recombinant DNA technology in a mammalian cell expression system

 

Pharmacology of Humira (Abbott Laboratories)

Used in the treatment of rheumatoid arthritis. Elevated levels of TNF are found in the synovial fluid of rheumatoid arthritis patients and play an important role in both the pathologic inflammation and the joint destruction that are hallmarks of the disease. Humira (Abbott Laboratories) binds specifically to TNF-alpha and blocks its general cytokine effects, thereby reducing TNF-induced inflammation and halting the joint destruction.

 

Humira (Abbott Laboratories) for patients

 

Humira (Abbott Laboratories) Interactions

Methotrexate

HUMIRA has been studied in rheumatoid arthritis patients taking concomitant MTX. The data do not suggest the need for dose adjustment of either HUMIRA or MTX.

Anakinra

Concurrent administration of anakinra (an interleukin-1 antagonist) and another TNF-blocking agent has been associated with an increased risk of serious infections, an increased risk of neutropenia and no additional benefit compared to these medicinal products alone. The safety and efficacy of anakinra used in combination with HUMIRA has not been studied. Therefore the, combination of anakinra with other TNF-blocking agents, including HUMIRA, may also result i n similar toxicities.

 

Humira (Abbott Laboratories) Contraindications

HUMIRA should not be administered to patients with known hypersensitivity to HUMIRA or any of its components.

 

Additional information about Humira (Abbott Laboratories)

Humira (Abbott Laboratories) Indication

For treatment of rheumatoid arthritis

Mechanism Of Action
Humira (Abbott Laboratories) binds to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors. Humira (Abbott Laboratories) also lyses surface TNF expressing cells in vitro in the presence of complement.
Generic Name
Adalimumab
Synonyms
Ig gamma-1 chain C region
Drug Category
Antirheumatic Agents; Immunomodulatory Agents
Drug Type
Biotech; Approved
Other Brand Names containing Adalimumab
Humira (Abbott Laboratories);
Biotransformation
Most likely removed by opsonization via the reticuloendothelial system.
Half Life
10-20 days.
Dosage Forms of Humira (Abbott Laboratories)
Solution Subcutaneous
Chemical IUPAC Name
Humanized anti-TNF antibody (D2E7)
Chemical Formula
C6428H9912N1694O1987S46
Organisms Affected
Humans and other mammals